Volume 4, Issue 1 (Spring & Summer 2020)                   J Res Urol 2020, 4(1): 10-18 | Back to browse issues page

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Sabzghabaei F, Mahmoodi V, Pouladi M, Yassin Z, soltani P. Risk Factors of Acute Kidney Injury in Patients with Sepsis; A Cross-Sectional Study. J Res Urol 2020; 4 (1) :10-18
URL: http://urology.umsha.ac.ir/article-1-71-en.html
Risk Factors of Acute Kidney Injury in Patients with Sepsis; A Cross-Sectional Study
Foroogh Sabzghabaei1 , Vahid Mahmoodi *2 , Masoume Pouladi3 , Zeynab Yassin4 , Parnian Soltani5
1- Department of Nephrology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Resident of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran , drdesperado58@gmail.com
3- Resident of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran
4- Antimicrobial Resistance Research Center, Iran University of Medical Sciences, Tehran, Iran
5- Medical doctor, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (6089 Views)
Background and Objective: Due to the importance of acute kidney injury associated in patients with sepsis and the impact of various factors on mortality and hospital stay of these patients, this study was conducted to investigate the clinical features and risk factors for acute kidney injury in patients with sepsis. In addition, we examined whether the severity of acute kidney injury affected clinical outcomes.
Methods: This was a cross-sectional study performed on patients admitted with sepsis in Firoozgar Hospital between 2018 and 2020. Patients were divided into two groups, those with and without acute kidney injury, to compare baseline and laboratory characteristics. 
Results: In total, 380 patients entered. Acute kidney injury (AKI) occurred in 41.1% of patients with sepsis. Analysis of multivariate logistic regression showed that the risk of acute kidney injury significantly was associated with older age, history of ischemic heart disease, hypertension and diabetes, smoking and drug abuse, use of ACEI and ARB medications, presence of bacteremia, presence of tissue infection as sepsis etiology, low serum albumin, and high AST levels, delayed antibiotic and fluid therapy, and vasopressor administration. Hospital mortality and length of hospital stay were higher in the AKI group.
Conclusion: Septic AKI had a negative effect on clinical outcomes. Also, the severity of acute kidney injury was associated with increased short-term mortality, length of hospital stay, and the need for dialysis.
Keywords: Acute kidney injury, Sepsis, Risk factors, Mortality
Full-Text [PDF 433 kb]   (2202 Downloads)    
Type of Study: Research | Subject: Endourology
Received: 2020/06/27 | Accepted: 2020/08/21 | Published: 2020/09/16
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