Volume 7, Issue 1 (Spring & Summer 2023)
J Res Urol 2023, 7(1): 21-29 |
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Khosravinia H, Yousefi B, Baharvand Y, Baharvand P. Comparison of Certain Hematological Indices, Prostate Volume, and Prostate-specific Antigen Level in Diabetic and Non-Diabetic Males with Benign Prostate Hypertrophy. J Res Urol 2023; 7 (1) :21-29
URL: http://urology.umsha.ac.ir/article-1-139-en.html
URL: http://urology.umsha.ac.ir/article-1-139-en.html
1- Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Lorestan, Iran , khosravi_fafa@yahoo.com
2- Department of Urology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Lorestan, Iran
3- Department of Oncology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Lorestan, Iran, Faculty of Medicine
4- Department of Social Medicine, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Lorestan, Iran
2- Department of Urology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Lorestan, Iran
3- Department of Oncology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Lorestan, Iran, Faculty of Medicine
4- Department of Social Medicine, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Lorestan, Iran
Abstract: (613 Views)
Background and Objective: This study aimed to compare certain hematological indices, prostate volume, and prostate-specific antigen (PSA) level in diabetic and non-diabetic males with benign prostate hypertrophy (BPH).
Materials and Methods: Data on age, body mass index, 11 hematological indices, and prostate-related variables were collected from the relevant documents for 55 diabetic and 60 non-diabetic male patients hospitalized with BPH diagnosis in Shohadaye Ashayer Hospital in Khoramabbad, Iran, during 2021-2022. The collected data were analyzed using t-test, regression, and correlation analysis in a statistical analysis system.
Results: Blood glucose concentration and prostate volume were greater by 75 mg (44%) and 26 mL (26%) in diabetic patients, respectively, compared to nondiabetic patients (P<0.01). Serum absolute and relative concentrations of PSA in diabetic patients were greater by 0.4 mg and 5.4 mg/mL, respectively, compared to the nondiabetic patients (P>0.05). Moreover, prostate volume was increased by 0.047 and 0.18 mL (four-fold greater) in nondiabetic and diabetic patients, respectively. Besides, correlation values and trends were different between diabetic and nondiabetic patients in terms of certain parameters.
Conclusion: It can be concluded that the pathophysiology of BPH may differ in relation to the greater blood glucose concentrations and its neuropathies in diabetic patients.
Materials and Methods: Data on age, body mass index, 11 hematological indices, and prostate-related variables were collected from the relevant documents for 55 diabetic and 60 non-diabetic male patients hospitalized with BPH diagnosis in Shohadaye Ashayer Hospital in Khoramabbad, Iran, during 2021-2022. The collected data were analyzed using t-test, regression, and correlation analysis in a statistical analysis system.
Results: Blood glucose concentration and prostate volume were greater by 75 mg (44%) and 26 mL (26%) in diabetic patients, respectively, compared to nondiabetic patients (P<0.01). Serum absolute and relative concentrations of PSA in diabetic patients were greater by 0.4 mg and 5.4 mg/mL, respectively, compared to the nondiabetic patients (P>0.05). Moreover, prostate volume was increased by 0.047 and 0.18 mL (four-fold greater) in nondiabetic and diabetic patients, respectively. Besides, correlation values and trends were different between diabetic and nondiabetic patients in terms of certain parameters.
Conclusion: It can be concluded that the pathophysiology of BPH may differ in relation to the greater blood glucose concentrations and its neuropathies in diabetic patients.
Keywords: Blood cell ratios, Benign prostate hyperplasia, Diabetes mellitus, Prostate-specific antigen, Prostate volume
Type of Study: Research |
Subject:
Urologic oncology
Received: 2023/10/30 | Accepted: 2024/01/12 | Published: 2024/08/31
Received: 2023/10/30 | Accepted: 2024/01/12 | Published: 2024/08/31
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