Volume 7, Issue 1 (Spring & Summer 2023)
J Res Urol 2023, 7(1): 30-37 |
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Azadbakht B, Saremi A, Khansooz M. Effect of a Resistance Training Period on Some Apoptotic Markers in Kidney Tissue of Diabetic Male Rats with Morphine Withdrawal Syndrome. J Res Urol 2023; 7 (1) :30-37
URL: http://urology.umsha.ac.ir/article-1-135-en.html
URL: http://urology.umsha.ac.ir/article-1-135-en.html
1- Department of Physical Education, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2- Research Institute for Applied Studies in Sport Sciences, Arak University, Arak, Iran ,a-saremi@araku.ac.ir
2- Research Institute for Applied Studies in Sport Sciences, Arak University, Arak, Iran ,
Abstract: (347 Views)
Background and Objective: This study aimed to investigate the effect of resistance training on some apoptotic markers of kidney tissue with morphine withdrawal syndrome in diabetic rats.
Materials and Methods: In this experimental study, 32 male Wistar rats were randomly divided into four groups of eight, namely groups with diabetes, morphine diabetes, diabetes + resistance training, and diabetes morphine + resistance training. After the implementation of the diabetes induction protocol, the addicted groups received morphine orally for 21 days, while the training groups participated in the resistance training protocol for 8 weeks. Afterward, all the mice were killed and dissected and their kidney tissue was removed. Enzyme-linked immunosorbent Assay kits were used to evaluate apoptotic factors.
Results: Cytochrome-C variable results showed a significant decrease in the morphine diabetes (P=0.002), diabetes + resistance training (P=0.001), and morphine diabetes + resistance training (P=0.001) groups, compared to the diabetes group. Results of the caspase-8 variable also indicated that the diabetes + resistance training group underwent a significant decrease, compared to the diabetes (P=0.004) and morphine diabetes group (P=0.012). Furthermore, the reduction of caspase 3 variable results in the morphine diabetes (P=0.001), diabetes + resistance training (P=0.001), and morphine diabetes + resistance training (P=0.002) groups was significant, compared to the diabetes group.
Conclusion: Resistance training reduces apoptotic indices in kidney tissue and can be a suitable treatment strategy for diabetes and withdrawal syndrome diabetes.
Materials and Methods: In this experimental study, 32 male Wistar rats were randomly divided into four groups of eight, namely groups with diabetes, morphine diabetes, diabetes + resistance training, and diabetes morphine + resistance training. After the implementation of the diabetes induction protocol, the addicted groups received morphine orally for 21 days, while the training groups participated in the resistance training protocol for 8 weeks. Afterward, all the mice were killed and dissected and their kidney tissue was removed. Enzyme-linked immunosorbent Assay kits were used to evaluate apoptotic factors.
Results: Cytochrome-C variable results showed a significant decrease in the morphine diabetes (P=0.002), diabetes + resistance training (P=0.001), and morphine diabetes + resistance training (P=0.001) groups, compared to the diabetes group. Results of the caspase-8 variable also indicated that the diabetes + resistance training group underwent a significant decrease, compared to the diabetes (P=0.004) and morphine diabetes group (P=0.012). Furthermore, the reduction of caspase 3 variable results in the morphine diabetes (P=0.001), diabetes + resistance training (P=0.001), and morphine diabetes + resistance training (P=0.002) groups was significant, compared to the diabetes group.
Conclusion: Resistance training reduces apoptotic indices in kidney tissue and can be a suitable treatment strategy for diabetes and withdrawal syndrome diabetes.
Type of Study: Research |
Subject:
Reconstructive urology
Received: 2023/09/2 | Accepted: 2023/10/19 | Published: 2024/08/31
Received: 2023/09/2 | Accepted: 2023/10/19 | Published: 2024/08/31
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