Volume 8, Issue 2 (Fall & Winter 2025)
J Res Urol 2025, 8(2): 83-91 |
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Danaei H, Zargham M, Gholipour F, Karimifar M, mansouri A. Investigation of the Relationship between Hypothyroidism Treatment and Lower Urinary Tract Symptoms in Women with Diabetes: A Retrospective Cohort Study in Isfahan from 2010 to 2020. J Res Urol 2025; 8 (2) :83-91
URL: http://urology.umsha.ac.ir/article-1-171-en.html
URL: http://urology.umsha.ac.ir/article-1-171-en.html
1- , mah_zargham@yahoo.com
Abstract: (355 Views)
Background and Objective: Diabetes and hypothyroidism are prevalent conditions among women that can lead to neuropathy and dysfunction of the lower urinary tract. This study aimed to investigate the association between hypothyroidism treatment and lower urinary tract symptoms (LUTS) in diabetic women in Isfahan from 2010 to 2020.
Materials and Methods: In this retrospective cohort study, the exposed group consisted of women who had been diagnosed with both diabetes and hypothyroidism for a minimum of five years (since at least 2016) and experienced LUTS. The non-exposed group included diabetic women with at least five years of disease history who also reported LUTS but had no diagnosis of hypothyroidism. The severity of LUTS was compared between the two groups using the ICIQ-FLUTS long form questionnaire. Data were analyzed in SPSS software (version 27) using the Mann-Whitney U test, independent sample t-test, and Pearson Chi-Square test.
Results: The findings from the age-adjusted comparison between the exposed group (n=162) and the non-exposed group (n=196) indicated no statistically significant difference between them in terms of the frequency and severity of LUTS, as well as the incidence of recurrent urinary tract infection (P>0.05).
Conclusion: Hypothyroidism might not affect the severity or frequency of urinary symptoms in diabetic women diagnosed with LUTS. It appears that diabetes plays a more prominent role as the main factor in the development and exacerbation of urinary symptoms.
Materials and Methods: In this retrospective cohort study, the exposed group consisted of women who had been diagnosed with both diabetes and hypothyroidism for a minimum of five years (since at least 2016) and experienced LUTS. The non-exposed group included diabetic women with at least five years of disease history who also reported LUTS but had no diagnosis of hypothyroidism. The severity of LUTS was compared between the two groups using the ICIQ-FLUTS long form questionnaire. Data were analyzed in SPSS software (version 27) using the Mann-Whitney U test, independent sample t-test, and Pearson Chi-Square test.
Results: The findings from the age-adjusted comparison between the exposed group (n=162) and the non-exposed group (n=196) indicated no statistically significant difference between them in terms of the frequency and severity of LUTS, as well as the incidence of recurrent urinary tract infection (P>0.05).
Conclusion: Hypothyroidism might not affect the severity or frequency of urinary symptoms in diabetic women diagnosed with LUTS. It appears that diabetes plays a more prominent role as the main factor in the development and exacerbation of urinary symptoms.
Keywords: Hypothyroidism, Lower urinary tract symptoms, Urinary bladder diseases, Urination disorders
Type of Study: Research |
Subject:
Urogynecology - Female urology
Received: 2025/03/12 | Accepted: 2025/08/15 | Published: 2025/12/23
Received: 2025/03/12 | Accepted: 2025/08/15 | Published: 2025/12/23
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