Prophylactic Antibiotic Therapy with a Combination of Intravenous and Oral Ciprofloxacin and Metronidazole to Prevent Prostate Infection and Sepsis during Transrectal Prostate Biopsy: A Retrospective Study

Tavoosian, Ali; Ahmadi, Sana

Volume 8, Issue 2 (Fall & Winter 2025) J Res Urol 2025, 8(2): 69-74 | Back to browse issues page

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Tavoosian A, Ahmadi S. Prophylactic Antibiotic Therapy with a Combination of Intravenous and Oral Ciprofloxacin and Metronidazole to Prevent Prostate Infection and Sepsis during Transrectal Prostate Biopsy: A Retrospective Study. J Res Urol 2025; 8 (2) :69-74
URL: http://urology.umsha.ac.ir/article-1-165-en.html

Prophylactic Antibiotic Therapy with a Combination of Intravenous and Oral Ciprofloxacin and Metronidazole to Prevent Prostate Infection and Sepsis during Transrectal Prostate Biopsy: A Retrospective Study

Ali Tavoosian ^*¹

, Sana Ahmadi

1- , alitavoosian@gmail.com

Abstract: (428 Views)

Background and Objective: The financial burden and inefficient use of human resources associated with prostate cancer represent major public health concerns, driving health researchers and urologists to prioritize early detection and timely treatment. Intrarectal biopsy is considered one of the most effective and straightforward techniques for diagnosing prostate cancer, offering fewer complications and greater ease compared to alternative methods. Despite its advantages, this technique carries a notable risk of causing infections in the prostate and urinary tract, which has led to the common use of prophylactic antibiotics to mitigate these complications.
Materials and Methods: In this retrospective study conducted at a medical center over a 5-year period, 52 male patients aged 50 to 75 years who underwent transrectal prostate biopsy under ultrasound guidance were treated with a prophylactic combined antibiotic regimen consisting of ciprofloxacin (administered in both injectable and oral forms) and metronidazole (also administered in both injectable and oral forms).
Results: Within one month following the procedure, all 52 patients returned for a physical examination and follow-up consultation. During this evaluation, none reported any signs of infection such as fever, chills, nausea, vomiting, urethral discharge, or urinary symptoms.
Conclusion: The researchers of this retrospective study intend to introduce a combined prophylactic antibiotic regimen that has been tested on 52 male patients over a period of five years. The regimen has been reported to be safe, low-cost, and highly effective in preventing post-biopsy urogenital infections, particularly acute prostatitis, with a success rate of 100%.

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Type of Study: Applicable | Subject: Endourology
Received: 2024/12/9 | Accepted: 2025/01/28 | Published: 2025/12/23

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