Volume 4, Issue 2 (Fall & Winter 2020)
J Res Urol 2020, 4(2): 52-58 |
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Izadpanahi M H, Manavi P, Alizadeh F, Mohammadi M, Khorrami M H, Adineh E. The Effect of Diabetes Mellitus on Serum Level of Prostate Specific Antigen. J Res Urol 2020; 4 (2) :52-58
URL: http://urology.umsha.ac.ir/article-1-78-en.html
URL: http://urology.umsha.ac.ir/article-1-78-en.html
Mohammad Hossein Izadpanahi1 
, Parisa Manavi * 2, Farshid Alizadeh3 , Mehrdad Mohammadi3 , Mohammad Hatef Khorrami4 , Ehsan Adineh5
, Parisa Manavi * 2, Farshid Alizadeh3 , Mehrdad Mohammadi3 , Mohammad Hatef Khorrami4 , Ehsan Adineh5
1- Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2- School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran ,dr.parinaz@gmail.com
3- Associate Professor, Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4- Professo, rDepartment of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5- Medical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2- School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran ,
3- Associate Professor, Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4- Professo, rDepartment of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5- Medical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract: (5122 Views)
Background and Objective: The aim of this study was to assess the effect of diabetes mellitus on Prostate Specific Antigen (PSA) serum levels among diabetic males without urinary tract complaints.
Methods: This is a case-control study conducted on 75 diabetic cases and 75 age-matched non-diabetic ones in 2016-17. Patients' demographics including age, duration of diabetes mellitus, presence of diabetic nephropathy, serum PSA (total and free) were recorded and cases were compared with controls.
Results: Diabetic patients and controls were not statistically different regarding their age (P=0.61). Level of total and free PSA and their ratio were significantly less in diabetic group (P<0.001). Pearson coefficient correlation test showed no statistical association between duration of diabetes mellitus with PSA indices (P>0.05). There was significant association between HbA1C with total and free PSA and their ratio. Insulin therapy was in association with total and free PSA and their ratio (P<0.05) but oral remedies were not (P>0.05).
Conclusion: Diabetic persons have lower levels of all PSA indices. Findings of this study showed inverse statistical association of HbA1C with PSA indices while no association was found with duration of diabetes. PSA indices were significantly lower among patients under insulin therapy but no difference was found considering routine oral therapies.
Methods: This is a case-control study conducted on 75 diabetic cases and 75 age-matched non-diabetic ones in 2016-17. Patients' demographics including age, duration of diabetes mellitus, presence of diabetic nephropathy, serum PSA (total and free) were recorded and cases were compared with controls.
Results: Diabetic patients and controls were not statistically different regarding their age (P=0.61). Level of total and free PSA and their ratio were significantly less in diabetic group (P<0.001). Pearson coefficient correlation test showed no statistical association between duration of diabetes mellitus with PSA indices (P>0.05). There was significant association between HbA1C with total and free PSA and their ratio. Insulin therapy was in association with total and free PSA and their ratio (P<0.05) but oral remedies were not (P>0.05).
Conclusion: Diabetic persons have lower levels of all PSA indices. Findings of this study showed inverse statistical association of HbA1C with PSA indices while no association was found with duration of diabetes. PSA indices were significantly lower among patients under insulin therapy but no difference was found considering routine oral therapies.
Keywords: Diabetes mellitus, Prostate specific antigen, Diabetic nephro-pathy, Prostate cancer, Benign prostate hyperplasia
Type of Study: Research |
Subject:
Endourology
Received: 2021/02/11 | Accepted: 2021/07/7 | Published: 2021/09/4
Received: 2021/02/11 | Accepted: 2021/07/7 | Published: 2021/09/4
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