Introduction: Urinary incontinence is any urine leakage without control from bladder that is classified into persistent incontinence, urge incontinence, overflow incontinence and stress incontinence. Stress incontinence is more prevalent than another types of incontinence and results in economy expenses and social costs. . In this study, we compared the transurethral platelet rich plasma combined with autologous fat injection versus autologous fat injection on abdominal leak point pressure in patients with stress urinary incontinence in Hamadan’s Beheshti Hospital.

Materials and Methods: In this clinical trial study, we studied female patients with stress urinary incontinence in Hamadan’s Beheshti hospital from September 2012 to March 2012. Platelet rich plasma combined with autologous fat were injected into the patient’s bladder neck as a bulking agent. Data were analyzed using SPSS 16. At the end, all analyses were compared at 95 percent level of confidence. Paired t-test statistical analysis was used. Significant level was considered less than 0.05.

Results: The interior – posterior thickness of injected fat tissue along with PRP in MRI and also the level of ALPP increased significantly and the symptoms in patients improved based on questionnaires data.

Conclusions: With regard to different aspects of our study such as the intensity of urinary incontinence in accordance with the questionnaire, changes of thickness in fat tissue using MRI in Sagittal sections, changes in ALPP using Urodynamic and complications resulting from the treatment, the obtained results were promising and its seems that this is one of the treatment options recommended to the patients. Its seems that PRP+FAT may be used as factors to treat females with stress urinary incontinence.