fa پرولاپس اعضای لگنی و ویتامین D:کشف تأثیر بر کیفیت زندگی ارولوژی زنان Urogynecology - Female urology پژوهشي Research <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">مقدمه: </span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">پرولاپس اعضای لگنی</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> (POP) </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">یک وضعیت شایع است که میلیون‌ها زن در سراسر جهان را تحت تأثیر قرار می‌دهد. ویتامین</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> D </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در تنظیم قدرت عضلانی و تعدیل التهاب نقش داشته و آن را به عاملی بالقوه در توسعه</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> POP </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">تبدیل می‌کند</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">.</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">این مطالعه با هدف بررسی تأثیر مکمل آنالوگ ویتامین</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> D </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">بر قدرت عضله لواتور و بیان گیرنده ویتامین</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> D (VDR) </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در افراد مبتلا به پرولاپس رحمی انجام شد</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">روش&shy;کار: </span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">تعداد </span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">۴۰۰</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> زن </span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">۵۰</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> تا </span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">۷۴</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> ساله در این مطالعه مورد-شاهد مورد بررسی قرار گرفتند و به گروه آزمون با</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> POP </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">و گروه کنترل بدون</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> POP </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">تقسیم شدند. ارزیابی‌های مختلف شامل معاینات زنان، نمونه‌گیری خون برای سطوح ویتامین</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> D </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">و پرسشنامه‌های ناراحتی کف لگن انجام شد</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">یافته ها: </span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتایج نشان داد که کمبود ویتامین</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> D </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">با آسیب کف لگن در زنان یائسه ارتباط دارد. مطالعه نشان داد که گروه‌های آزمون و کنترل توزیع سنی مشابهی داشتند که اعتبار یافته‌ها را تقویت کرد. علاوه بر این، چندزایی به عنوان عامل مؤثر بالقوه در توسعه پرولاپس شناسایی شد که نشان‌دهنده ارتباط بین تعداد زایمان‌های واژینال و وقوع پرولاپس است. تفاوت‌های قابل توجهی در بی‌اختیاری ادراری استرسی و اختلال کارکرد کف لگن بین گروه‌های آزمون و کنترل مشاهده شد</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">بحث: </span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">این مطالعه نقش بالقوه ویتامین</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> D </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در پرولاپس اعضای لگنی و اهمیت در نظر گیری زایمان و اختلالات زمینه‌ای در درک علت‌شناسی آن را برجسته می‌کند. تحقیقات بیشتری برای کشف پتانسیل درمانی مکمل ویتامین</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> D </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">و تأثیرات آن بر قدرت عضله لواتور و بیان</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> VDR </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در افراد مبتلا به پرولاپس رحمی مورد نیاز است</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Introduction:</span></span></b><span new="" roman="" style="font-family:" times=""> Pelvic organ prolapse (POP) is a common condition affecting millions of women worldwide. Vitamin D has been implicated in muscle strength regulation and inflammation modulation, making it a potential factor in POP development. This study aimed to investigate the impact of vitamin D analog supplementation on levator muscle strength and vitamin D receptor (VDR) expression in individuals with uterine prolapse.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">&nbsp;<b>Methods:</b></span></span><span new="" roman="" style="font-family:" times=""> A total of 400 women aged 50 to 74 years were included in this case control study, divided into a test group with POP and a control group without POP. Various assessments, including gynecological examinations, blood sampling for vitamin D levels, and pelvic floor discomfort questionnaires, were conducted.</span><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b> <span new="" roman="" style="font-family:" times="">The results revealed thatVitamin D deficiency was associated with pelvic floor damage in postmenopausal women. The study found that the test and control groups had a similar age distribution, strengthening the validity of the findings. Furthermore, multiparity was identified as a potential contributing factor to prolapse development, suggesting a relationship between the number of vaginal births and prolapse occurrence. Significant differences were observed in stress urinary incontinence and pelvic floor distress between the test and control groups.</span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="text-autospace:none"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b> <span new="" roman="" style="font-family:" times="">This study highlights the potential role of vitamin D in pelvic organ prolapse and the importance of considering parity and background disorders in understanding its etiology. Further research is needed to explore the therapeutic potential of vitamin D supplementation and its effects on levator muscle strength and VDR expression in individuals with uterine prolapse.</span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span><br> &nbsp; پرولاپس اعضای لگنی؛ ویتامین D؛ بی‌اختیاری ادراری Pelvic organs prolapse, vitamin D, Urinary incontinency 0 0 http://urology.umsha.ac.ir/browse.php?a_code=A-10-156-6&slc_lang=fa&sid=1 Farshad Banouei فرشاد بانویی farshadbanouei90@gmail.com 10031947532846004896 10031947532846004896 Yes Hamedan university دانشگاه علوم پزشکی